Stone dust and cement are usually used as filler in asphalt-concrete mixture in Bangladesh. This study has made to prepare asphalt-concrete mixtures using non-conventional fillers which are locally available. Bangladesh is a developing country, where cost is the main concern for any type of constructions. From this point of view, the prime aim of this investigation has been set out to examine the effect of non-conventional filler such as non-plastic sand, brick dust and ash as a filler replacement on the performance of asphalt-concrete mixture and to compare the characteristics of asphalt-concrete mixtures with conventional ones according to the test procedure specified by AASHTO. From the experimental data, it is observed that the value of Marshall Stability is comparatively higher by using non-plastic sand than other non-conventional filler materials. It is also observed that brick dust and ash requires higher asphalt content because of their higher absorption capabilities. The retained strength of the asphalt-concrete mixture using non-plastic sand, brick chips and ash are approximately 89%, 87% and 84% respectively which satisfies the limiting value 75%. Based on this experimental program, it is verified that inclusion of non-conventional filler can be efficiently used in asphalt-concrete mixture as a filler replacement from the viewpoint of stability, deformation and voids characteristics.