Rice is a major crop in the world and South Kivu. However, its cultivation still underdeveloped in our country, more than 200,000 tons of rice were imported in 2010.manystudies have shown that high yields can be produced in the province of South Kivu, which could contribute to the reduction of these imports. The use of fertilizers is one of the strategies for increasing rice production in the world. The experimental design used was the split plot with as main plot the variety (VO46 and FC56) and the secondary type of fertilizer (NPK, Manure, NPK-Manure and a control). The combination of these two factors gave us a total of 8 treatments including 6 from the combination of variety with fertilizers and 2 corresponding controls to variety grown without fertilization. These treatments were repeated three times. We proceeded to the germination and transplanting of 2 plantlet per planting hole at the spacing of 25x20 cm. The farm manure used at transplanting period (71gr / pouch) and 13g of NPK 17-17-17 or the NPK-Manure combination was hanged per pouch. The results showed that there are statistically significant differences between treatments (fertilizers) and between the varieties studied (P = 0.011). Control plots yielded an average yield lower than fertilized plots. In addition, the plots fertilized with NPK alone yielded a lower average yield (3.4 t / ha) than those of the other plots fertilized (5.4 t / ha) but higher than that of the control. The VO46 variety fertilized with the NPK-mixed organic fertilizer gave a significantly high yield (5.4 t / ha) compared to the FC56 variety (4.1 t / ha) fertilized with the same combination.