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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Thursday 20 June 2019

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Antihyperglycaemic and Antihyperproteinaemic Activity of Extracts of Picralima nitida Seed and Tapinanthus bangwensis Leaf on Alloxan-Induced Diabetic Rabbits


Volume 3, Issue 4, August 2013, Pages 1125–1131

 Antihyperglycaemic and Antihyperproteinaemic Activity of Extracts of Picralima nitida Seed and Tapinanthus bangwensis Leaf on Alloxan-Induced Diabetic Rabbits

Bosede M. Adegoke1 and Oyelola B. Oloyede2

1 Department of Applied Sciences, Osun State Polytechnic, Iree, Osun State, Nigeria
2 Department of Biochemistry, University of Ilorin, Ilorin, Kwara State, Nigeria

Original language: English

Received 6 June 2013

Copyright © 2013 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Coconut water extract of Picralima nitida seed and aqueous extract of Tapinanthus bangwensis leaf were investigated for their antidiabetic activities on some biochemical parameters (glucose, protein) associated with diabetes in both the serum and tissues of experimental animals using alloxan-induced diabetic rabbits as model. The rabbits were fasted overnight before they were given a single intraperitoneal injection of aqueous alloxan monohydrate (Sigma, USA) at a dose of 300 mg/kg body weight to make them diabetic. The experimental rabbits (chinchilla) were grouped into six and extracts administered orally, once daily for five weeks. Groups 1 and 2 (non-diabetic) received only distilled water and coconut water respectively, group 3 (diabetic) received 200 mg/kg body weight aqueous extract of T. bangwensis leaf, group 4 received 400 mg/kg body weight of coconut water extract of P. nitida seed, groups 5 and 6 (diabetic) received only distilled water and coconut water respectively. The results revealed that the extracts independently lowered significantly (p<0.05) the blood glucose and protein levels of the diabetic rabbits. Both extracts significantly (p<0.05) increased the tissue protein. Overall, aqueous extract of T. bangwensis leaf and coconut water extract of P. nitida seed independently possesses insulin-like properties as demonstrated by their antidiabetic actions, hence, may be good herbal extracts in the management of diabetes.

Author Keywords: Alloxan, Antihyperglycaemic, Antihyperproteinaemic, Diabetes, Picralima nitida, Tapinanthus bangwensis.


How to Cite this Article


Bosede M. Adegoke and Oyelola B. Oloyede, “Antihyperglycaemic and Antihyperproteinaemic Activity of Extracts of Picralima nitida Seed and Tapinanthus bangwensis Leaf on Alloxan-Induced Diabetic Rabbits,” International Journal of Innovation and Applied Studies, vol. 3, no. 4, pp. 1125–1131, August 2013.