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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Monday 27 January 2020

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Preparation and Characterization of Sodium Alginate Nanoparticles Containing ICD-85 (Venom Derived Peptides)


Volume 4, Issue 3, November 2013, Pages 534–542

 Preparation and Characterization of Sodium Alginate Nanoparticles Containing ICD-85 (Venom Derived Peptides)

Saeed Moradhaseli1, Abbas Zare Mirakabadi2, Ali Sarzaeem3, Nasser Mohammadpour dounighi4, Saman Soheily5, and Mehrasa Rahimi Borumand6

1 Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran
2 Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran
3 Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran
4 Department of Human Vaccine and Serum, Razi Vaccine and Serum Research Institute, Karaj, Iran
5 Department of Biology, Payame Noor University, Tehran, Iran
6 Department of Chemistry, Faculty of Sciences, Shahr-e-ray Branch, Islamic Azad University, Tehran, Iran

Original language: English

Received 7 August 2013

Copyright © 2013 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Sodium alginate is one of such biodegradable polymers, which has been extensively exploited for the preparation of nanoparticles (NPs) for controlled delivery of several therapeutic agents. ICD-85 (venom derived peptides) has been shown to exhibit anti-cancer activity. In this report sodium alginate nanoparticles employed to improve upon its effectiveness. ICD-85 loaded NPs were prepared by ionic gelation method and were characterized by the particle size, zeta potential, transmission electron microscopy, FT-IR spectroscopy and in vitro release studies. The in vitro cytotoxicity was evaluated by MTT assay. TEM revealed ICD-85 loaded NPs to have spherical shapes with a size of approximately 200 nm. The zeta potential of the ICD-85 loaded NPs was estimated as

Author Keywords: ICD-85, Nanoparticles, Encapsulation, Sodium alginate, Ionic gelation, HEp-2 cell line.


How to Cite this Article


Saeed Moradhaseli, Abbas Zare Mirakabadi, Ali Sarzaeem, Nasser Mohammadpour dounighi, Saman Soheily, and Mehrasa Rahimi Borumand, “Preparation and Characterization of Sodium Alginate Nanoparticles Containing ICD-85 (Venom Derived Peptides),” International Journal of Innovation and Applied Studies, vol. 4, no. 3, pp. 534–542, November 2013.