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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Friday 25 May 2018

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  Call for Papers - May 2018     |     Now IJIAS is indexed in EBSCO, ResearchGate, ProQuest, Chemical Abstracts Service, Index Copernicus, IET Inspec Direct, Ulrichs Web, Google Scholar, CAS Abstracts, J-Gate, UDL Library, CiteSeerX, WorldCat, Scirus, Research Bible and getCited, etc.  
 
 
 

Effect of Hormone Replacement Therapy on Osteoporosis and Its Complication on Adults Female Albino Rats


Volume 6, Issue 2, June 2014, Pages 203–209

 Effect of Hormone Replacement Therapy on Osteoporosis and Its Complication on Adults Female Albino Rats

Marwan A. Ibrahim1

1 Assistant Professor of Applied Physiology, Department of Medical Laboratories, Majmaah University/ Faculty of science, Zulfi, Riyadh, Saudi Arabia

Original language: English

Received 9 May 2014

Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


This study was conducted to show whether hormonal replacement treatment would offer ameliorating effects against abnormal alterations associated with osteoporosis in female albino rats. Two experiments were carried out, in the first experiment, the rats were randomly divided into two main groups. The first group, were let without surgery and served as control while, the second group were obeyed to bilateral ovariectomy surgery to induce osteoporosis; after 4 weeks induced acute hormonal disturbance indicated by decreased estradiols and progesterone levels. While, the level of follicular stimulating hormone and luteinizing hormone were increase in osteoporosis female rats regarding to levels in normal control female rats. In the second experiment, a remarkable correction was occurred in the levels of follicular stimulating hormone and luteinizing hormone by gradually decreased after 90 days of treatment. While, a considerable amelioration effect was occurred in the estradiols level by gradually increasing of levels with the time and treatment with estrogen replacement. These corrections were dependent on the time of treatment (30, 60 & 90 days). According to the pre-mentioned results, it is importance to concluding that the treatment with estradiol replacement ameliorates chance of recovery from hazardous effects of osteoporoses. The obtained data were discussed according to available obtained researches.

Author Keywords: Hormonal treatment, Osteoporosis, female albino rats, estradiol, ovariectomy.


How to Cite this Article


Marwan A. Ibrahim, “Effect of Hormone Replacement Therapy on Osteoporosis and Its Complication on Adults Female Albino Rats,” International Journal of Innovation and Applied Studies, vol. 6, no. 2, pp. 203–209, June 2014.