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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Monday 20 May 2019

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DETERMINATION THE OPTIMUM FERMENTATION IN OBTAINING NATTOKINASE BY BACILLUS SUBTILIS NATTO


Volume 13, Issue 3, November 2015, Pages 663–668

 DETERMINATION THE OPTIMUM FERMENTATION IN OBTAINING NATTOKINASE BY BACILLUS SUBTILIS NATTO

Nguyen Anh Tuan1, Dinh Thi Hai Thuan2, Tran Thi Minh Tam3, and Nguyen Thuy Huong4

1 Department of Biotechnology, Ho Chi Minh City University of Technology, Vietnam
2 Department of Biotechnology, Ho Chi Minh City University of Technology, Vietnam
3 Department of Biotechnology, Ho Chi Minh City University of Technology, Ho Chi Minh, Vietnam
4 Department of Biotechnology, Ho Chi Minh City University of Technology, Ho Chi Minh, Vietnam

Original language: English

Received 19 April 2015

Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Nattokinase is able to hydrolyze fibri oriented fibers, reducing blood pressure to the arteries and heart valves. People use nattokinase enzyme through ingestion by natto food or functional food to dissolve blood clots. In fermentation by Bacillus subtilis natto, the bacterium can generate this enzyme. The optimized culture medium has 6 factors such as glucose, soybean peptone, K2HPO4, MgSO4, NaCl, CaCl2 and the rate of these in medium is identified by response furface methodology (RSM) and central composite design (CCD). The highest nattokinase yield was 69.3

Author Keywords: extracellular proteases, Nattokinase activity, optimized experiments, Plackett.


How to Cite this Article


Nguyen Anh Tuan, Dinh Thi Hai Thuan, Tran Thi Minh Tam, and Nguyen Thuy Huong, “DETERMINATION THE OPTIMUM FERMENTATION IN OBTAINING NATTOKINASE BY BACILLUS SUBTILIS NATTO,” International Journal of Innovation and Applied Studies, vol. 13, no. 3, pp. 663–668, November 2015.