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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Tuesday 16 July 2019

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An Approach to Design & Development and Evaluation of Aceclofenac Floating Pellets Using Sodium Alginate and HPMC (HPMC K4M & HPMC K100LV) as polymer


Volume 4, Issue 2, October 2013, Pages 447–455

 An Approach to Design and Development and Evaluation of Aceclofenac Floating Pellets Using Sodium Alginate and HPMC (HPMC K4M and HPMC K100LV) as polymer

Umme Hani Khanam1, Swati Paul2, and Dibyajyoti Saha3

1 Standard Laboratories Limited, Chittagong, Bangladesh
2 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh
3 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh

Original language: English

Received 9 August 2013

Copyright © 2013 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


The present study was conducted to investigate the effect of Na-alginate and hydroxyl propyl methyl cellulose (HPMC) polymer combination of Aceclofenac floating pellets. The Aceclofenac pellets were prepared with two different grades of HPMC polymers in the ratio of 2:1, 1:2 and 1.5:1.5 respectively while the amounts of Na-alginate used in the formulations was 3.50, 5.25 and 7.0g. Prepared pellets were evaluated by Particle size and Morphology, Contraction ratio, Moisture content, Friability Test, Swelling study, Buoyancy time and floating time of the pellets were examined on the basis of polymer concentration. The contraction ratio of the particle was highest when pellets were prepared with 1.5% Na- alginate solution and the polymer ratio was 1:2 (BX, BY, BZ). In case of Buoyancy of Pellets, When Alginate concentration was 1% and HPMC K4M & HPMC K100LV ratio was 2:1 then, the Aceclofenac pellets were not floated for long time. When the concentration of Na-Alginate increased to 1.5%, 2%, then all pellets were floated. In case of swelling study, CY, BZ, CZ showed highest swelling of approximately 8% when Na-alginate concentration was (1.5 % , 2%, 2 %) and BY and CY batches showed lowest swelling of 2.9% at 4hrs when Na-alginate concentration was 1.5 %. Friability values for each formulation were recorded in table the values of the preferred formulas are within acceptable limit. Thus, the selection and use of suitable polymers in appropriate ratio is very important in designing floating pellets of Aceclofenac.

Author Keywords: Na-alginate, Aceclofenac, Methocel, Floating Pellet, Polymer.


How to Cite this Article


Umme Hani Khanam, Swati Paul, and Dibyajyoti Saha, “An Approach to Design & Development and Evaluation of Aceclofenac Floating Pellets Using Sodium Alginate and HPMC (HPMC K4M & HPMC K100LV) as polymer,” International Journal of Innovation and Applied Studies, vol. 4, no. 2, pp. 447–455, October 2013.